595 Outcomes of Two-Stage Revision Surgery of Oncology Endoprostheses for Prosthetic Joint Infection

Abstract Aim We aim to report the outcomes of two-stage revision surgery eradicate periprosthetic joint infection (PJI) endoprostheses in orthopaedic oncology. Method A retrospective review 44 patients who underwent PJI between 1999 and 2018 was conducted at a single tertiary oncology centre. The mean age 36.1 years (12–78). sites prostheses were distal femur 50%, proximal 11.4%, tibia 36.4% total with replacement 2%. follow-up period 6.9 (range 0.4–19 years). Results overall rate eradication for 95.2% 2 (95% CI 89–100%) 79% 67–93%) 5 years. Amputation free survival over 100% 88% 78–99.8%). There no difference incidence reinfection recurrence amputation silver-coated implants. Coagulase-negative staphylococcus most common microorganism, isolated 21 patients. Infection successfully eradicated 54.5%. Polymicrobial recorded 18%. Multi-drug resistance (MDR) organisms 48% cohort. Conclusions MDR polymicrobial are oncological lower clearance rates than primary arthroplasty group. increased attempts limb salvage treat may explain infection-free compared previous series same centre, which reported higher as their initial management.